WIKINDX Resources
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Han Xiaoning, Chen Michael & Wang Fushun et al. (2013). « Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice ». Cell Stem Cell, vol. 12, n° 3, mars, p. 342–353. ISSN 1934-5909. En ligne : <http://www.sciencedirec ... e/pii/S1934590913000076>.
Added by: Catherine Reverdy (25 Jul 2013 11:45:31 Europe/Paris) Last edited by: Catherine Reverdy (25 Jul 2013 13:59:34 Europe/Paris) |
| Resource type: Journal Article DOI: 10.1016/j.stem.2012.12.015 ID no. (ISBN etc.): 1934-5909 BibTeX citation key: Han2013  |
Categories: Apprentissages et psychologie Subcategories: Neurosciences et Ă©ducation Keywords: neurosciences Creators: Bekar, Betstadt, Chen, Goldman, Han, Nedergaard, Oberheim, Shanz, Silva, Takano, Wang, Wang, Windrem, Xu Collection: Cell Stem Cell |
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| URLs http://www.science ... /S1934590913000076 |
| Abstract |
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Summary Human astrocytes are larger and more complex than those of infraprimate mammals, suggesting that their role in neural processing has expanded with evolution. To assess the cell-autonomous and species-selective properties of human glia, we engrafted human glial progenitor cells ({GPCs)} into neonatal immunodeficient mice. Upon maturation, the recipient brains exhibited large numbers and high proportions of both human glial progenitors and astrocytes. The engrafted human glia were gap-junction-coupled to host astroglia, yet retained the size and pleomorphism of hominid astroglia, and propagated Ca2+ signals 3-fold faster than their hosts. Long-term potentiation ({LTP)} was sharply enhanced in the human glial chimeric mice, as was their learning, as assessed by Barnes maze navigation, object-location memory, and both contextual and tone fear conditioning. Mice allografted with murine {GPCs} showed no enhancement of either {LTP} or learning. These findings indicate that human glia differentially enhance both activity-dependent plasticity and learning in mice. Video Abstract
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